Down syndrome is the most common genetic cause of intellectual disability, the most common autosomal trisomy, and one of the most visible and universally recognized genetic syndromes. Each year there
With additional funding, this directive provided NIH with the opportunity to expand its current efforts on Down syndrome and commonly co-occurring conditions in individuals with Down syndrome. This NIH-wide initiative, INvestigating Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE), allowed NIH to build an integrated effort across NIH that is truly transformative in these areas. It was guided by a research plan focusing on projects in areas that matter to the lives of individuals with Down syndrome and their families. The INCLUDE research plan for FY2018 and beyond is further described below.